The truth behind the collagen food supplement everyone is talking about

Is there really any difference between the countless collagen products on the market? That depends on who you ask. With so much conflicting information from supplement companies, social media, and high-profile personalities, it’s getting harder and harder to know what to believe. Read on to learn the surprising, science-backed truth that even most industry experts don’t know.


Collagen is a protein that provides structure to cells and can be found in nearly every part of the human body, especially in healthy skin, and connective tissue. Your body starts to decrease collagen production in your 20s. In fact, you lose about 1% of your collagen every year, so by age 50 you have nearly 30% less collagen than you did at age 20, and almost 50% less collagen by the time you’re 70.

Collagen loss is the number one internal factor that contributes to noticeable signs of ageing. Once it begins to break down, the intracellular matrix loses its rigidity and structural support, leading to the appearance of sagging skin and wrinkles.


Collagen as a nutritional ingredient can be classified into one of several groups depending on its type, source, and manufacturing processes. The most popular varieties of collagen include:

TYPE I: Hydrolyzed — Derived from porcine skin, bovine hide, eggshell membrane, or fish, this collagen type is commonly sold as bone broth or collagen powder.

TYPE II: Undenatured, unhydrolyzed collagen — Mostly derived from chickens.

TYPE III: Hydrolyzed — Often derived from bovine sources.

Vegan collagen: A pending scientific development in attempts to meet consumer demand, using genetically modified yeast and bacteria.

NOTE: Vegan collagen is not yet commercially available at the time of this publication. Products that are misleadingly labeled as vegan collagen typically contain no collagen at all but instead are formulated with common collagen-boosting ingredients such as vitamin C to capitalize on consumer demand.

If you’ve ever heard that ingestible collagen doesn’t provide any benefits, that’s partly true. In their natural state, collagen molecules are too large to be effectively absorbed by the body and are simply digested as proteins in the digestive system.

Hydrolysis is a process that breaks down these large collagen molecules for improved efficacy, so most supplements use hydrolyzed collagen. However, the method of hydrolyzation and the type and source of collagen used can yield widely varying results in the quality and effectiveness of the end product. What’s more, there’s also a very different kind of collagen that goes beyond the usual categories named above.


Liquid BioCell® is a unique type II collagen that goes beyond the typical hydrolyzed bovine or marine collagen found in most formulas. This award-winning, single-source matrix has been shown to restore youthful skin.

Backed by multi-patented Collagen/HA Matrix™ Technology, this proprietary ingredient is naturally derived from chicken sternal cartilage and hydrolyzed using a patented Bio-Optimized™ manufacturing process to achieve an ideal macromolecule.

The result is a naturally enhanced bioavailability. Bioavailability has a direct bearing on how beneficial a supplement is because it measures how efficiently a substance enters a body’s circulatory system. Ingesting a nutrient is not enough; it must be absorbed to derive any benefit, so the bioavailability of a supplement can be just as important as, if not more so than, what its supplement facts panel may claim.


As the gold standard for supplemental collagen since its launch, Liquid BioCell® has inspired ground-breaking trends that have since been attempted by other brands, like a collagen matrix ingredient. Even so, Liquid BioCell® still stands alone in delivering all of these scientifically demonstrated benefits, backed by multiple scientific studies for results you can see and feel:


  • Improves skin’s hydration, firmness, and elasticity
  • Increases skin’s collagen content
  • Reduces the appearance of deep wrinkles and lines
  • Reduces hyaluronidase, the enzyme that causes skin aging

In scientific studies, hyaluronic acid levels increased by 6000% over 28 days reducing wrinkles from the inside out.

In scientific studies, dryness was reduced by 76% without the use of a topical moisturizer at 12 weeks.

What’s more, Liquid BioCell® is scientifically shown to reduce hyaluronate, an enzyme that significantly contributes to skin ageing.

In fact, the Bio-Optimized™ collagen in Liquid BioCell® may even directly activate chondrocytes (cartilage cells) to stimulate the body to produce its own new collagen.


Modere delivers premium collagen you can depend on for effective, scientifically demonstrated results backed by a commitment to clean label ingredients and packaging. The Liquid BioCell® line currently includes gluten-free and dairy-free formulas to deliver targeted benefits for a wide range of ages and lifestyles.

Nearly two decades in the making, Liquid BioCell® bridges the gap between nutrition and beauty. A pioneer in the industry, it’s one of the most widely recognized collagen brands in the United States and has earned global recognition and multiple awards.

  • 2020 NUTRACHAMPION (awarded to Modere CEO Asma Ishaq for innovation in collagen)
  • FINALIST, PRODUCT INNOVATION AWARD (awarded for Trim) DSA Awards, 2018
  • #1 ANTI-AGING ESSENTIAL TasteForLife Supplement Essentials, 2015
  • READER’S INGREDIENT OF THE YEAR Nutraingredients Awards Winner, 2015
  • EDITOR’S PICK Remedies Magazine, 2015
  • FINALIST, MOST INNOVATIVE DIETARY INGREDIENT Nutraceutical Business & Technology Award, 2012
  • EXEMPLARY US BRAND RECOGNITION Beauty From Within Conference, 2011
  • ANTI-AGING FEATURE PRODUCT – Good Morning America, 2010

Beyond the awards, scientific studies and third-party validation for Liquid BioCell®, its Collagen/HA Matrix™ Technology is backed by multiple US and international patents.


The innovations pioneered by Liquid BioCell have set new precedents in the industry. While many companies have since followed our lead, none can match the unique combination of this single-source collagen, the Collagen/HA Matrix® composition and Bio-Optimized® micromolecule that makes Liquid BioCell® so effective. Only Liquid BioCell offers all of the following:

  • Multiple industry awards
  • 7 U.S. and international patents
  • Scientifically demonstrated benefits,
  • Naturally sourced matrix of hydrolyzed type II collagen
  • Patented Bio-Optimized™ process that results in the ideal molecular weight for enhanced absorption
  • Liquid delivery system
  • Concentrated formula, requiring only 2 tablespoons per day
  • Multi-faceted benefits extend to skin


1. Where can I find more information about studies on Liquid BioCell®?

More information about studies on Liquid BioCell® can be found on individual Liquid BioCell® product pages. Additionally, a list of scientific references can be found at the end of this document.

2. How do I know Modere scientific studies are valid?

Our independent research is conducted via multiple scientific studies and is third-party validated. These criteria are universally considered the highest standard for scientific studies in the scientific community.

3. Can you see visible results?

These are pictures of what Liquid BioCell has done for real people who took the daily dose for 12 weeks†.

4. Have any studies on Liquid BioCell® been published in medical journals?

Although selected studies on our ingredient have been published in peer-reviewed journals, Modere opts to strictly limit the publication of studies on Liquid BioCell in scientific journals in order to protect proprietary data.

5. Where can I find trustworthy information about collagen?

Collagen is a buzzword right now, not only among social media influencers and beauty bloggers but in the medical community as well. Unfortunately, many so-called “experts” are inadvertently spreading misinformation about collagen supplementation. Popular media figures and even physicians who make generalizations about unproven or false claims by manufacturers are often not educated on the latest research. Attempts to discredit collagen supplements do not take into account our scientific studies, which show that the unique Collagen/HA Matrix™ in Liquid BioCell® works very differently than typical hydrolyzed collagen.

When shopping for a collagen supplement, look for one that is backed by scientific research. Make sure that the research cited includes direct references to the specific ingredient or product you’re considering.

6. Is it safe to take multiple collagen products at the same time?

While we can’t speak for other collagen brands, Liquid BioCell® has been demonstrated to be well-tolerated at doses up to 30 times the recommended daily dosage of two tablespoons (30 ml) per day, according to toxicology studies. The recommended serving size is based on the dose determined to deliver the studied benefits.

Modere products featuring Liquid BioCell® include our Trim product line.

For a full daily serving when taking Liquid BioCell® alongside other Modere collagen products, you may mix and match your custom program based on the following recommended serving sizes:


1 Tbsp Liquid BioCell® (all formulas)         = 1/2 daily dose

1 Tbsp Trim (all flavors) = 1/2 daily dose

As with any supplement, it is always recommended that you speak with your physician before starting a new regimen and disclose any other supplements you may be taking.

1. Does Liquid BioCell® interfere with other drugs?

Liquid BioCell® is not a drug; it is a nutritional supplement. There is no evidence that Liquid BioCell® interferes with any medications. However, if you’re on medication, we recommend that you speak with your physician before starting any new supplement.

2. Is it harmful to take collagen while pregnant?

No studies have been done on Liquid BioCell® during pregnancy. We encourage you to speak with your physician before starting a new supplement, whether or not you are pregnant.


Hyaluronic acid in cutaneous intrinsic aging. Ghersetich et al. 1994, Int J Dermatol, pp. 33(2): 119-122.

Hyaluronic acid stimulates human …within a collagen matrix. Greco et al. 1998, J Cell Physiol, pp. 177(3): 465-473.

A randomized double-blind clinical pilot trial evaluating the safety and efficacy of hydrolyzed collagen type II (BioCell Collagen II®) in adults with …. Sheldon et al. 2003, Miami Research Associates.

Acute and subchronic oral toxicity studies in rats of a hydrolyzed chicken sternal cartilage preparation. Schauss et al. 2007, Food Chem

Toxicol, pp. 45: 315-321.

Chronic ultraviolet B irradiation causes loss of hyaluronic acid from mouse dermis because of down-regulation of hyaluronic acid synthases.

Dai et al. 2007, Am J Path, pp. 282: 1451-1561.

Hyaluronan facilitates transformation … Meran et al. 2008, J Biol Chem, pp. 283: 6530-6545.

Native hyaluronic acid in dermatology—results of an expert meeting. Wiest et al. J Dtsch Dermatol Ges, 2008, pp. 6: 176-180.

Collagen fragmentation promotes oxidative stress and elevates matrix metalloproteinase-1 in fibroblasts in aged human skin. Fisher et al.

2009, Am J Path, pp. 174: 101-114.

† Actual results from a Modere Independent Representative. Individual results may vary.

  • Independent Modere representative